Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA.

@article{Montie2009AutophagyAA,
  title={Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA.},
  author={Heather L. Montie and Diane E. Merry},
  journal={Autophagy},
  year={2009},
  volume={5 8},
  pages={1194-7}
}
Ridding neurons of toxic misfolded proteins is a critical feature of many neurodegenerative diseases. We have recently reported that lack of access of nuclear polyglutamine-expanded androgen receptor (AR) to the autophagic degradation pathway is a critical point in pathogenesis. When mutant AR is contained within the cytoplasm, it can be degraded by autophagy, resulting in amelioration of its toxic effects, as has been observed in other polyglutamine expansion diseases involving cytoplasmic… CONTINUE READING

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