Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts.

Abstract

BACKGROUND Knock-in mice provide useful models of congenital and age-related cataracts caused by α-crystallin mutations. R49C αA-crystallin and R120G αB-crystallin mutations are linked with hereditary cataracts. Knock-in αA-R49C+/- heterozygotes develop cataracts by 1-2months, whereas homozygote mice have cataracts at birth. The R49C mutation drastically… (More)
DOI: 10.1016/j.bbagen.2015.06.001

Topics

5 Figures and Tables

Slides referencing similar topics