Autophagy and Lipid Droplets in the Liver.

@article{MartinezLopez2015AutophagyAL,
  title={Autophagy and Lipid Droplets in the Liver.},
  author={Nuria Martinez-Lopez and Rajat Singh},
  journal={Annual review of nutrition},
  year={2015},
  volume={35},
  pages={215-37}
}
Autophagy is a conserved quality-control pathway that degrades cytoplasmic contents in lysosomes. Autophagy degrades lipid droplets through a process termed lipophagy. Starvation and an acute lipid stimulus increase autophagic sequestration of lipid droplets and their degradation in lysosomes. Accordingly, liver-specific deletion of the autophagy gene Atg7 increases hepatic fat content, mimicking the human condition termed nonalcoholic fatty liver disease. In this review, we provide insights… CONTINUE READING
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