Autophagy and Aging: The Importance of Maintaining "Clean" Cells

@article{Cuervo2005AutophagyAA,
  title={Autophagy and Aging: The Importance of Maintaining "Clean" Cells},
  author={A. Cuervo and E. Bergamini and U. Brunk and W. Dröge and M. Ffrench and A. Terman},
  journal={Autophagy},
  year={2005},
  volume={1},
  pages={131 - 140}
}
A decrease in the rate of protein turnover and the intracellular accumulation of altered proteins in cytosol and membranes are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related manifestations. In this work we review the molecular defects responsible for the malfunctioning of two forms of autophagy - macroautophagy and chaperone-mediated autophagy - in old mammals, and highlight general and cell-type specific consequences of dysfunction of… Expand

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