Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism.

Abstract

Thiamine deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the brain, which may be mediated by neuronal oxidative stress, endoplasmic reticulum (ER) stress, and neuroinflammation. TD-induced brain damage is used to model neurodegenerative disorders, and the mechanism for the neuronal death is still unclear… (More)
DOI: 10.1111/jnc.12268

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