Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

@inproceedings{Newman2017AutophagyAT,
  title={Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins},
  author={Alice C Newman and Alain J. Kemp and Yvette Drabsch and Christian Behrends and Simon C. Wilkinson},
  booktitle={Nature Communications},
  year={2017}
}
Macroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mechanisms. We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A549 cells in vitro, yet promotes tumorigenesis in mice. ATG5 represses transcriptional activation by the TGFβ-SMAD gene regulatory pathway. However, autophagy does not… CONTINUE READING