Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells

@inproceedings{Zhou2016AutophagyAP,
  title={Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells},
  author={Y. Zhou and Qing-xia Wang and Hai-yan Zhou and Gang Chen},
  booktitle={Acta Pharmacologica Sinica},
  year={2016}
}
Aim:The inhaled anesthetic sevoflurane may induce cognitive impairment in both animals and humans. Previous study has shown that sevoflurane triggers ER stress and may lead to apoptosis in rat hippocampal neurons. In this study, we examined whether sevoflurane caused autophagy and its contributions to sevoflurane induced neuronal cell injury.Methods:H4 human neuroglioma cells were exposed to 4.1% sevoflurane for 6 h. Cell viability and apoptosis ratio were assessed using a CCK8 kit and flow… CONTINUE READING

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