Autophagy activation contributes to glutathione transferase Mu 1-mediated chemoresistance in hepatocellular carcinoma

  title={Autophagy activation contributes to glutathione transferase Mu 1-mediated chemoresistance in hepatocellular carcinoma},
  author={Xiu-tao Fu and Kang Song and Jian Zhou and Yinghong Shi and Wei-ren Liu and Meng-Xin Tian and Lei Jin and Guoming Shi and Qiang Gao and Zhen-Bin Ding and Jia Fan},
  journal={Oncology Letters},
  pages={346 - 352}
Glutathione transferase Mu 1 (GSTM1) induces cancer drug resistance by hydrolyzing cancer chemotherapeutics or activating the anti-apoptosis pathway. However, the chemoresistance-inducing mechanism of GSTM1 in hepatocellular carcinoma (HCC) remains unknown. In the present study, the expression of GSTM1 was examined in three HCC cell lines. Oxaliplatin and sorafenib were selected as chemotherapeutic agents. Small interfering RNA was used to decrease GSTM1 expression. Cell death was measured… 

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