Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy.

@article{Liu2015AutophagyLysosomePI,
  title={Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy.},
  author={Wei Jing Liu and Ting Ting Shen and Rui Chen and Hong-luan Wu and Yan Jin Wang and Jian Kun Deng and Qiu Hua Chen and Qingjun Pan and Chang-mei Huang Fu and Jing-li Tao and Dong Liang and Hua-Feng Liu},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 33},
  pages={20499-510}
}
It has been suggested that autophagy protects renal tubular epithelial cells (TECs) from injury in diabetic nephropathy (DN). However, the manner in which the autophagy-lysosome pathway is changed in this state remains unclear. In this study of DN, we investigated the autophagic activity and lysosomal alterations in vivo and in vitro. We found that autophagic vacuoles and SQSTM1-positive proteins accumulated in TECs from patients with DN and in human renal tubular epithelial cell line (HK-2… CONTINUE READING
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