Autophagy Induced by HIF1α Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy

@inproceedings{YamanakaTatematsu2013AutophagyIB,
  title={Autophagy Induced by HIF1α Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy},
  author={Mikiko Yamanaka-Tatematsu and Akitoshi Nakashima and Naonobu Fujita and Tomoko Shima and Tamotsu Yoshimori and Shigeru Saito},
  booktitle={PloS one},
  year={2013}
}
Extravillous trophoblasts (EVTs) characterize the invasion of the maternal decidua under low oxygen and poor nutrition at the early feto-maternal interface to establish a successful pregnancy. We previously reported that autophagy in EVTs was activated under 2% O2 in vitro, and autophagy activation was also observed in EVTs at the early feto-maternal interface in vivo. Here, we show that autophagy is an energy source for the invasion of EVTs. Cobalt chloride (CoCl2), which induces hypoxia… CONTINUE READING

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