Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.

@article{Park2016AutophagyGE,
  title={Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.},
  author={Sunmin Park and Michael D. Buck and Chandni Desai and Xin Zhang and Ekaterina Loginicheva and Jennifer Martinez and Michael L Freeman and Tatsuya Saitoh and Shizuo Akira and Jun-Lin Guan and Y W He and Marcia A Blackman and Scott A Handley and Beth Levine and Douglas R Green and Tiffany A. Reese and Maxim N. Artyomov and Herbert W Virgin},
  journal={Cell host & microbe},
  year={2016},
  volume={19 1},
  pages={91-101}
}
Host genes that regulate systemic inflammation upon chronic viral infection are incompletely understood. Murine gammaherpesvirus 68 (MHV68) infection is characterized by latency in macrophages, and reactivation is inhibited by interferon-γ (IFN-γ). Using a lysozyme-M-cre (LysMcre) expression system, we show that deletion of autophagy-related (Atg) genes Fip200, beclin 1, Atg14, Atg16l1, Atg7, Atg3, and Atg5, in the myeloid compartment, inhibited MHV68 reactivation in macrophages. Atg5… CONTINUE READING
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