Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.

  title={Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.},
  author={Zhaoju Wu and Pei-Ching Chang and Joy C. Yang and C L Chu and Ling-yu Wang and N R Chen and A Ma and Sonal J. Desai and Su Hao Lo and Christopher P Evans and Kit Sang Lam and Hsing-Jien Kung},
  journal={Genes & cancer},
  volume={1 1},
There is overwhelming evidence that tyrosine kinases play an important role in cancer development. As a prototype of targeted therapy, tyrosine kinase inhibitors are now successfully applied to cancer treatment. However, as single agents, tyrosine kinase inhibitors have not achieved satisfactory results in the treatment of prostate cancer, principally due to their inability to efficiently kill tumor cells. The authors' laboratory has been interested in the role of the Src complex in prostate… CONTINUE READING
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A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study

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