Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury.

@article{Dong2010AutophagyDM,
  title={Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury.},
  author={Yi Dong and Vishnu Vardhan Reddy Undyala and Roberta A Gottlieb and Robert M. Mentzer and Karin Przyklenk},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  year={2010},
  volume={15 3},
  pages={220-30}
}
Autophagy is the endogenous, tightly regulated cellular "housekeeping" process responsible for the degradation of damaged and dysfunctional cellular organelles and protein aggregates. There is a growing consensus that autophagy is upregulated in the setting of myocardial ischemia-reperfusion. Moreover, emerging data suggest that autophagy may serve as an… CONTINUE READING