Autophagy: cancer therapy's friend or foe?

  title={Autophagy: cancer therapy's friend or foe?},
  author={Dan Grand{\'e}r and Theocharis Panaretakis},
  journal={Future medicinal chemistry},
  volume={2 2},
Autophagy is a physiological process that is activated not only in response to stress (e.g., degradation of damaged organelles or nutrient starvation) but also during carcinogenesis and tumor progression. Furthermore, a number of commonly used anticancer drugs activate the autophagic program, a response that, in most cases, suppresses the cytotoxic effects of the drugs, where in some other cases, autophagy promotes drug-induced cell death. Significant progress has been made on delineating the… CONTINUE READING


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