Autophagy: Regulation by Energy Sensing

  title={Autophagy: Regulation by Energy Sensing},
  author={Alfred J. Meijer and Patrice Codogno},
  journal={Current Biology},
Autophagy is inhibited by the mTOR signaling pathway, which is stimulated by increased amino acid levels. When cellular energy production is compromised, AMP-activated protein kinase is activated, mTOR is inhibited and autophagy is stimulated. Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux.