Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger.

@article{Mathew2011AutophagySA,
  title={Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger.},
  author={Robin Mathew and Eileen White},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2011},
  volume={76},
  pages={389-96}
}
Altered metabolism is a hallmark of cancer. Oncogenic events that lead to cancerous states reorganize metabolic pathways to increase nutrient uptake, which promotes biosynthetic capabilities and cell-autonomous behavior. Increased biosynthesis dictates metabolic demand for ATP, building blocks, and reducing equivalents, rendering cancer cells metabolically in a perpetually hungry state. Moreover, most chemotherapy agents induce acute metabolic stress that cancer cells must overcome for their… CONTINUE READING
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