Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.

  title={Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.},
  author={Jeffrey N. Keller and Edgardo R. Dimayuga and Qinghua Chen and Jeffrey R Thorpe and Jillian R. Gee and Qunxing Ding},
  journal={The international journal of biochemistry & cell biology},
  volume={36 12},
In order to successfully respond to stress all cells rely on the ability of the proteasomal and lysosomal proteolytic pathways to continually maintain protein turnover. Increasing evidence suggests that as part of normal aging there are age-related impairments in protein turnover by the proteasomal proteolytic pathway, and perturbations of the lysosomal proteolytic pathway. Furthermore, with numerous studies suggest an elevated level of a specialized form of lysosomal proteolysis (autophagy or… CONTINUE READING
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