Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron.

@article{Kurz2007AutophagyAA,
  title={Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron.},
  author={Tino Kurz and Alexei Terman and Ulf T. Brunk},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={462 2},
  pages={220-30}
}
As an outcome of normal autophagic degradation of ferruginous materials, such as ferritin and mitochondrial metalloproteins, the lysosomal compartment is rich in labile iron and, therefore, sensitive to the mild oxidative stress that cells naturally experience because of their constant production of hydrogen peroxide. Diffusion of hydrogen peroxide into the lysosomes results in Fenton-type reactions with the formation of hydroxyl radicals and ensuing peroxidation of lysosomal contents with… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

Lysosomal-mitochondrial cross-talk during cell death.

Mitochondrion • 2010
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…