Autophagosomes accumulate in differentiated and hypertrophic adipocytes in a p53-independent manner.

@article{Mikami2012AutophagosomesAI,
  title={Autophagosomes accumulate in differentiated and hypertrophic adipocytes in a p53-independent manner.},
  author={Kentaro Mikami and Naoyuki Okita and Yuki Tokunaga and Tomoyo Ichikawa and Tatsuya Okazaki and Kanako Takemoto and Wataru Nagai and Shingo Matsushima and Yoshikazu Higami},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={427 4},
  pages={758-63}
}
Autophagy is induced by several kinds of stress, including oxidative, genotoxic, endoplasmic reticulum and nutrient stresses. The tumor suppressor p53, which is a stress sensor, plays a critical role in the regulation of autophagy. Although p53 is required for starvation (nutrient deficient stress)-induced autophagy, it is still not clear whether p53 is… CONTINUE READING