Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion.

  title={Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion.},
  author={N. Ishihara and M. Hamasaki and S. Yokota and K. Suzuki and Y. Kamada and A. Kihara and T. Yoshimori and T. Noda and Y. Ohsumi},
  journal={Molecular biology of the cell},
  volume={12 11},
  • N. Ishihara, M. Hamasaki, +6 authors Y. Ohsumi
  • Published 2001
  • Biology, Medicine
  • Molecular biology of the cell
  • Double membrane structure, autophagosome, is formed de novo in the process of autophagy in the yeast Saccharomyces cerevisiae, and many Apg proteins participate in this process. [...] Key Result First, we showed that Sec18p (N-ethylmaleimide-sensitive fusion protein, NSF) and Vti1p (soluble N-ethylmaleimide-sensitive fusion protein attachment protein, SNARE), and soluble N-ethylmaleimide-sensitive fusion protein receptor are required for fusion of the autophagosome to the vacuole but are not involved in…Expand Abstract
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