Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells.

@article{Kawai2007AutophagosomelysosomeFD,
  title={Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells.},
  author={Akinori Kawai and Hiromi Uchiyama and Syuichi Takano and Nobuhiro Nakamura and Seitaro Ohkuma},
  journal={Autophagy},
  year={2007},
  volume={3 2},
  pages={
          154-7
        }
}
Autophagy is the bulk degradation of cytoplasmic constituents in response to starvation and other environmental or intracellular cues. During this process, most of the cytoplasm is sequestered into autophagosomes, which then fuse with lysosomes where the degradation of the sequestered material proceeds. We investigated the relationship between autophagosome-lysosome fusion and the pH in acidic compartments by visualizing the fusion process using fluorescence in CHO cells. In this experiment… CONTINUE READING
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