Autophagosome formation: core machinery and adaptations

@article{Xie2007AutophagosomeFC,
  title={Autophagosome formation: core machinery and adaptations},
  author={Zhiping Xie and Daniel J. Klionsky},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={1102-1109}
}
Eukaryotic cells employ autophagy to degrade damaged or obsolete organelles and proteins. Central to this process is the formation of autophagosomes, double-membrane vesicles responsible for delivering cytoplasmic material to lysosomes. In the past decade many autophagy-related genes, ATG, have been identified that are required for selective and/or nonselective autophagic functions. In all types of autophagy, a core molecular machinery has a critical role in forming sequestering vesicles, the… Expand
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