Autophagosome formation: core machinery and adaptations

  title={Autophagosome formation: core machinery and adaptations},
  author={Z. Xie and D. Klionsky},
  journal={Nature Cell Biology},
  • Z. Xie, D. Klionsky
  • Published 2007
  • Biology, Medicine
  • Nature Cell Biology
  • Eukaryotic cells employ autophagy to degrade damaged or obsolete organelles and proteins. Central to this process is the formation of autophagosomes, double-membrane vesicles responsible for delivering cytoplasmic material to lysosomes. In the past decade many autophagy-related genes, ATG, have been identified that are required for selective and/or nonselective autophagic functions. In all types of autophagy, a core molecular machinery has a critical role in forming sequestering vesicles, the… CONTINUE READING
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