Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.

@article{Yu2004AutophagicVA,
  title={Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.},
  author={Wai Haung Yu and Asok Kumar and Corrinne M. Peterhoff and L Shapiro Kulnane and Yasuo Uchiyama and Bruce T Lamb and Ana Mar{\'i}a Cuervo and Ralph A. Nixon},
  journal={The international journal of biochemistry & cell biology},
  year={2004},
  volume={36 12},
  pages={2531-40}
}
In Alzheimer's disease (AD), the neuropathologic hallmarks of beta-amyloid deposition and neurofibrillary degeneration are associated with early and progressive pathology of the endosomal-lysosomal system. Abnormalities of autophagy, a major pathway to lysosomes for protein and organelle turnover, include marked accumulations of autophagy-related vesicular compartments (autophagic vacuoles or AVs) in affected neurons. Here, we investigated the possibility that AVs contain the proteases and… CONTINUE READING