Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.

@article{Lopez2011AutophagicSI,
  title={Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.},
  author={Gonzalo Lopez and Keila E Torres and Juehui Liu and Belinda Hern{\'a}ndez and Eric D. Young and Roman Belousov and Svetlana Bolshakov and Alexander J F Lazar and John M. Slopis and Ian E. Mccutcheon and David McConkey and Dina Chelouche Lev},
  journal={Cancer research},
  year={2011},
  volume={71 1},
  pages={185-96}
}
Histone deacetylase inhibitors (HDACi) show promise as cancer therapeutics; however, the full scope of their utility remains unknown. Here we report findings that strongly rationalize clinical evaluation of HDACis in malignant peripheral nerve sheath tumors (MPNST), a class of highly aggressive, therapeutically resistant, and commonly fatal malignancies that occur sporadically or in patients with the inherited neurofibromatosis type-1 (NF1) syndrome. We evaluated the effects of the chemical… CONTINUE READING

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Determination of the class and isoform selectivity of small molecule HDAC inhibitors

  • N Khan, M Jeffers, S Kumar
  • Biochem J 2007;409:581–9
  • 2007
Highly Influential
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