Autophagic response to cell culture stress in pluripotent stem cells.

@article{Gregory2016AutophagicRT,
  title={Autophagic response to cell culture stress in pluripotent stem cells.},
  author={Sian Gregory and S. Swamy and Z. Hewitt and A. Wood and R. Weightman and H. Moore},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={473 3},
  pages={
          758-63
        }
}
Autophagy is an important conserved cellular process, both constitutively as a recycling pathway for long lived proteins and as an upregulated stress response. Recent findings suggest a fundamental role for autophagic processes in the maintenance of pluripotent stem cell function. In human embryonic stem cells (hESCS), autophagy was investigated by transfection of LC3-GFP to visualize autophagosomes and with an antibody to LC3B protein. The presence of the primary cilium (PC) in hESCs as the… Expand
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