Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

@article{Krger2012AutophagicDO,
  title={Autophagic degradation of tau in primary neurons and its enhancement by trehalose.},
  author={Ulrike Kr{\"u}ger and Yipeng Wang and Satish Kumar and E. -M. Mandelkow},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 10},
  pages={2291-305}
}
Modulating the tau level may represent a therapeutic target for Alzheimer's disease (AD), as accumulating evidence shows that Abeta-induced neurodegeneration is mediated by tau. It is therefore important to understand the expression and degradation of tau in neurons. Recently we showed that overexpressed mutant tau and tau aggregates are degraded via the autophagic pathway in an N2a cell model. Here we investigated whether autophagy is involved in the degradation of endogenous tau in cultured… CONTINUE READING