Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.

Abstract

Drug resistance of non-small cell lung cancer (NSCLC) is highly correlated to the mutation of the epidermal growth factor receptor (EGFR). Although EGFR tyrosine kinase inhibitors (TKIs) are available clinically, the molecular complexity of NSCLC has made it necessary to search for alternative therapeutic approaches to overcome the drug resistance of NSCLC… (More)
DOI: 10.3892/ijo.2016.3644

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