Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation

@article{Wang2018AutophagicMB,
  title={Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation},
  author={Ying Wang and Feng-Tao Liu and Yi-Xuan Wang and Rong-Yuan Guan and Chen Chen and Da-ke Li and Lu-Lu Bu and Jie Song and Yu-jie Yang and Yi Dong and Yan Chen and Jian Wang},
  journal={Neurotoxicity Research},
  year={2018},
  volume={34},
  pages={109-120}
}
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease characterized by the formation of protein inclusion and progressive loss of motor neurons, finally leading to muscle weakness and respiratory failure. So far, the effective drugs for ALS are yet to be developed. Impairment of transcriptional activator transcription factor EB (TFEB) has been demonstrated as a key element in the pathogenesis of ALS. Trehalose is an mechanistic target of rapamycin-independent… CONTINUE READING
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