Autophagic Cell Death in Dictyostelium Requires the Receptor Histidine Kinase DhkM

@inproceedings{Giusti2010AutophagicCD,
  title={Autophagic Cell Death in Dictyostelium Requires the Receptor Histidine Kinase DhkM},
  author={C. Giusti and Marie-Françoise Luciani and Sarina Ravens and Alexandre Gillet and Pierre Golstein},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Dictyostelium constitutes a genetically tractable model for the analysis of autophagic cell death (ACD). During ACD, Dictyostelium cells first transform into paddle cells and then become round, synthesize cellulose, vacuolize, and die. Through random insertional mutagenesis, we identified the receptor histidine kinase DhkM as being essential for ACD. Surprisingly, different DhkM mutants showed distinct nonvacuolizing ACD phenotypes. One class of mutants arrested ACD at the paddle cell stage… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

The IP3 receptor is required to signal autophagic cell death

D. Lam, A. Kosta, M. F. Luciani, P. Golstein
  • Mol. Biol. Cell
  • 2008
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Programmed cell death in Dictyostelium.

  • Journal of cell science
  • 1994
VIEW 8 EXCERPTS