Autooxidation as a basis for altered function by polymorphonuclear leukocytes.

@article{Baehner1977AutooxidationAA,
  title={Autooxidation as a basis for altered function by polymorphonuclear leukocytes.},
  author={Robert L. Baehner and Laurence Boxer and John M. Allen and John Y Davis},
  journal={Blood},
  year={1977},
  volume={50 2},
  pages={327-35}
}
To investigate the possibility that human polymorphonuclear leukocytes (PMN) elaborate sufficient amounts of hydrogen peroxide (H2O2) and other radicals of reduced oxygen to be autotoxic and retard directed cell movement and phagocytosis, the rate of ingestion of opsonized lipopolysaccharide-paraffin oil particles and movement through Nuclepore filters were studied. Ingestion rates were increased under anaerobic conditions and in normal aerobic conditions in the presence of extracellular… CONTINUE READING
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