Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM

@article{Scharnert2013AutonomousTA,
  title={Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM},
  author={Julia Scharnert and Lilo Greune and Dagmar Zeuschner and Marie-Luise Lubos and M Alexander Schmidt and Christian R{\"u}ter},
  journal={Cellular and Molecular Life Sciences},
  year={2013},
  volume={70},
  pages={4809-4823}
}
Extracellular Gram-negative pathogenic bacteria target essential cytoplasmic processes of eukaryotic cells by using effector protein delivery systems such as the type III secretion system (T3SS). These secretion systems directly inject effector proteins into the host cell cytoplasm. Among the T3SS-dependent Yop proteins of pathogenic Yersinia, the function of the effector protein YopM remains enigmatic. In a recent study, we demonstrated that recombinant YopM from Yersinia enterocolitica enters… CONTINUE READING
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