Autonomous replication sequences in an extrachromosomal element of a pathogenic Entamoeba histolytica.

@article{Grodberg1990AutonomousRS,
  title={Autonomous replication sequences in an extrachromosomal element of a pathogenic Entamoeba histolytica.},
  author={J Grodberg and Nuria Salazar and Ram Oren and david. mirelman},
  journal={Nucleic acids research},
  year={1990},
  volume={18 18},
  pages={5515-9}
}
Entamoeba histolytica possesses a 24.5 kilobase plasmid-like molecule which encodes for the organism's ribosomal RNAs. Sequence analysis of this extrachromosomal element revealed the presence of AT rich sequences which show homology to the origin of replication of other lower eucaryotes. An 802 bp fragment containing these sequences was cloned into a yeast shuttle vector lacking the origin of replication and the construct tested for its ability to replicate autonomously in yeast. Mitotic… CONTINUE READING

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