Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry

Abstract

Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes cyclin degradation and mitotic exit. The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cyclin A can accumulate in the presence of… (More)
DOI: 10.1038/nature03023

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