Autonomous nervous system innervation of lymphoid territories in spleen: A possible involvement of noradrenergic neurons for prion neuroinvasion in natural scrapie

@article{Bencsik2001AutonomousNS,
  title={Autonomous nervous system innervation of lymphoid territories in spleen: A possible involvement of noradrenergic neurons for prion neuroinvasion in natural scrapie},
  author={Anna A. Bencsik and St{\'e}phane Lezmi and Thierry Baron},
  journal={Journal of NeuroVirology},
  year={2001},
  volume={7},
  pages={447-453}
}
In experimental as well as in natural scrapie, transmissible spongiform encephalopathies (TSEs), the infectious agent, closely related to PrPsc, an abnormal isoform of the cellular prion protein, invades and replicates in lymphoid organs such as spleen before affecting the brain. To clarify the cellular requirements for the possible neuroinvasion of scrapie agent from the spleen to the central nervous system, we have studied the sympathetic innervation within the lymphoid territories of the… CONTINUE READING

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