Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence.

@article{Yoshimoto2012AutonomousMT,
  title={Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence.},
  author={Momoko Yoshimoto and Prashanth Porayette and Nicole L. Glosson and Simon J. Conway and Nadia Carlesso and Angelo Almeida Cardoso and Mark H Kaplan and Mervin C. Yoder},
  journal={Blood},
  year={2012},
  volume={119 24},
  pages={5706-14}
}
The extra-embryonic yolk sac (YS) is the first hematopoietic site in the mouse embryo and is thought to generate only primitive erythroid and myeloerythroid progenitor cells before definitive HSC emergence within the embryo on E10.5. Here, we have shown the existence of T cell-restricted progenitors in the E9.5 YS that directly engraft in recipient immunodeficient mice. T-cell progenitors were also produced in vitro from both YS and para-aortic splanchnopleura hemogenic endothelial cells, and… CONTINUE READING