Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.

@article{Meng2010AutonomousIV,
  title={Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.},
  author={Huan Meng and Min Xue and Tian Xia and Yan-Li Zhao and Fuyuhiko Tamanoi and J. Fraser Stoddart and Jeffrey I Zink and Andr{\'e} E Nel},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 36},
  pages={12690-7}
}
Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted… CONTINUE READING