Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy.

@article{Pittelkow1993AutonomousGO,
  title={Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy.},
  author={Mark R. Pittelkow and Paul W. Cook and Gary D. Shipley and Rik Derynck and Robert J Coffey},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1993},
  volume={4 6},
  pages={513-21}
}
In the studies reported here, we demonstrate that transforming growth factor alpha (TGF-alpha) or epidermal growth factor (EGF) is required for the establishment of small colonies of human keratinocytes at clonal densities, but once small (10-15 cells) colonies have formed, the continued growth of these colonies can proceed in the absence of exogenous TGF-alpha or EGF. Equivalent receptor-binding concentrations of TGF-alpha and EGF were equipotent in stimulating colony formation. We also… CONTINUE READING

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Keratinocyte abnormalities

  • M. R. Pittelkow
  • 1990

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