Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome

@article{Knyrim1981AutonomousCS,
  title={Autonomous cortisol secretion by a metastatic Leydig cell carcinoma associated with Klinefelter's syndrome},
  author={K. Knyrim and M. Higi and Dieter Kurt Hossfeld and Siegfried Seeber and Carl Gottfried Schmidt},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1981},
  volume={100},
  pages={85-93}
}
We present the case of a 39-year-old man with Klinefelter's syndrome and metastatic Leydig cell carcinoma in whom autonomous cortisol production induced by the interstitial cell tumor was found. Apart from the Cushing's syndrome the endocrine activity of the tumor was demonstrated by the secretion of estradiol, estrone, alkaline phosphatase, and… CONTINUE READING