Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

  title={Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation},
  author={Yochai Wolf and Anat Shemer and Michal Polonsky and Mor Gross and Alexander Mildner and Simon Yona and Eyal David and Ki-Wook Kim and Tobias Goldmann and Ido Amit and Mathias Heikenwalder and Sergei A. Nedospasov and Marco Prinz and Nir Friedman and Steffen Jung},
  booktitle={The Journal of experimental medicine},
Monocytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and differentiate into monocyte-derived macrophages and dendritic cells. Tumor necrosis factor (TNF) and its receptors are up-regulated during monopoiesis and expressed by circulating monocytes, as well as effector monocytes infiltrating certain sites of inflammation, such as the spinal cord, during experimental autoimmune encephalomyelitis (EAE). In this study, using competitive in vitro and in… CONTINUE READING
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