Autonomic reflexes and the cardiovascular effects of propylene glycol.

  title={Autonomic reflexes and the cardiovascular effects of propylene glycol.},
  author={D Al-Khudhairi and James G Whitwam},
  journal={British journal of anaesthesia},
  volume={58 8},
The effect of i.v. propylene glycol in doses of 160-800 mg kg-1 on heart rate, arterial pressure and efferent sympathetic activity were observed in anaesthetized paralysed, artificially ventilated dogs. Within 3-5 s of the commencement of the injection of propylene glycol there was an immediate mean decrease in heart rate of 22.7 and 72.1 beat min-1 and in arterial pressure of 27.2 and 58.8 mm Hg at doses of 400 mg kg-1 and 800 mg kg-1, respectively, together with a gross reduction of… CONTINUE READING


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