Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

@article{Taborsky1998AutonomicMO,
  title={Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.},
  author={Gerald J. Taborsky and Bo Ahr{\'e}n and P J Havel},
  journal={Diabetes},
  year={1998},
  volume={47 7},
  pages={
          995-1005
        }
}
This article examines the role of the autonomic nervous system in mediating the increase of glucagon secretion observed during insulin-induced hypoglycemia (IIH). In the first section, we briefly review the importance of the alpha-cell response in recovery from hypoglycemia under both physiologic conditions and pathophysiologic conditions, such as type 1 diabetes. We outline three possible mechanisms that may contribute to increased glucagon secretion during hypoglycemia but emphasize autonomic… CONTINUE READING

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