Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.

@article{Mitrani2007AutonomicII,
  title={Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.},
  author={Paul Mitrani and Malathi Srinivasan and Catherine Dodds and Mulchand S Patel},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 5},
  pages={
          E1364-77
        }
}
Exposure to a high-carbohydrate (HC) milk formula during the suckling period results in permanent metabolic programming of hyperinsulinemia in HC rats. Previous studies have shown that hyperinsulinemia in HC rats involves a programmed hyperresponsiveness to glucose. However, the immediate onset and persistence of enhanced insulin secretion throughout life suggests a role for numerous factors that control insulin secretion. Present in vivo and in vitro studies have shown a role for altered… 

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Metabolic programming effects initiated in the suckling period predisposing for adult-onset obesity cannot be reversed by calorie restriction.

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  • J. Janssen
  • Medicine, Biology
    International journal of molecular sciences
  • 2021
Interventions that normalize/reduce plasma insulin concentrations might play a key role in the prevention and treatment of age-related decline, obesity, type 2 diabetes, cardiovascular disease and cancer, and drugs that reduce insulin (hyper) secretion, normalize pulsatile insulin secretion and/or increase hepatic insulin clearance may also have the potential to prevent or delay the progression of hyperinsulinemia-mediated diseases.

Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium L-glutamate-obesity in mice.

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