Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.

@article{Mitrani2007AutonomicII,
  title={Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.},
  author={Paul Mitrani and Malathi Srinivasan and C Dodds and Mulchand S. Patel},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 5},
  pages={E1364-77}
}
Exposure to a high-carbohydrate (HC) milk formula during the suckling period results in permanent metabolic programming of hyperinsulinemia in HC rats. Previous studies have shown that hyperinsulinemia in HC rats involves a programmed hyperresponsiveness to glucose. However, the immediate onset and persistence of enhanced insulin secretion throughout life suggests a role for numerous factors that control insulin secretion. Present in vivo and in vitro studies have shown a role for altered… CONTINUE READING

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