Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice.

@article{Havel1993AutonomicCO,
  title={Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice.},
  author={P. Havel and Jones O. Akpan and Donald L. Curry and Judith S. Stern and Ronald L. Gingerich and Bo Ahr{\'e}n},
  journal={The American journal of physiology},
  year={1993},
  volume={265 1 Pt 2},
  pages={R246-54}
}
Neural control of pancreatic polypeptide (PP) release has not been previously investigated in the mouse. In addition, it is not known to what extent increased glucagon secretion during hypoglycemia in mice is neurally mediated vs. an effect of hypoglycemia to directly stimulate glucagon secretion at the level of the islet. Feeding or the cholinergic agonist carbachol increased plasma PP levels in conscious mice (+74 +/- 18 pg/ml vs. fasted mice and +141 +/- 17 pg/ml vs. control, respectively… CONTINUE READING

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