Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouse.

@article{Saba2003AutonomicBU,
  title={Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouse.},
  author={Samir F. Saba and B B Collier London and Leonard I. Ganz},
  journal={Journal of cardiovascular electrophysiology},
  year={2003},
  volume={14 2},
  pages={
          191-5
        }
}
INTRODUCTION In large animals, rate-dependent AV nodal (AVN) properties of conduction are modulated by autonomic inputs. In this study, we investigated whether the properties of AVN conduction and facilitation are altered by autonomic blockade in the mouse and whether this effect is age dependent. METHODS AND RESULTS Young (age 4-6 weeks; n = 11) and adult (age 8-9 months; n = 11) female mice underwent in vivo electrophysiologic testing, before and after autonomic blockade. After autonomic… CONTINUE READING
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