Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man

@article{Leonetti2004AutonomicAR,
  title={Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man},
  author={Gastonea Leonetti and Silvia Grazi and Alessia Ligresti and Salvatore Romano and Alberto Zanchetti},
  journal={Pharmacologia Clinica},
  year={2004},
  volume={2},
  pages={206-215}
}
Intravenous diazoxide produced an immediate marked hypotension in both mild and severe hypertensive patients. Depression of vasomotor reflexes, tested by the Valsalva overshoot, and of pressor responsiveness to noradrenaline was found only in the group of mild hypertensives. Decreased pressor reactivity to noradrenaline was not due to a nonspecific vascular… CONTINUE READING