Autonomic and cardiovascular effects of central neuromedin U in rats

@article{Tanida2009AutonomicAC,
  title={Autonomic and cardiovascular effects of central neuromedin U in rats},
  author={Mamoru Tanida and Jun Satomi and Jiao Shen and Katsuya Nagai},
  journal={Physiology & Behavior},
  year={2009},
  volume={96},
  pages={282-288}
}
Previous studies have demonstrated that neuromedin U (NMU) affects cardiovascular functions such as blood pressure (BP) or heart rate (HR) in rats. Here, we examined the effects of the lateral cerebral ventricular (ICV) injection of various doses of NMU on renal sympathetic nerve activity (RSNA) and BP in urethane-anesthetized rats. ICV injection of NMU elevated RSNA, BP and HR in a dose-dependent manner. Moreover, neither ICV pretreatment of thioperamide, an antagonist of histaminergic H3… CONTINUE READING

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