Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity

@inproceedings{Singhroy2012AutomethylationOP,
  title={Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity},
  author={Diane N Singhroy and Thibault Mespl{\`e}de and Arielle Sabbah and Peter Kojo Quashie and Jean-Pierre Falgueyret and Mark A. Wainberg},
  booktitle={Retrovirology},
  year={2012}
}
Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors. In addition, PRMT6 inhibits HIV-1 replication in cell culture by directly methylating and interfering with the functions of several HIV-1 proteins, i.e. Tat, Rev and nucleocapsid (NC). PRMT6 also displays automethylation capacity but the role of this post-translational modification in its antiretroviral activity remains unknown. Here we report the… CONTINUE READING
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