Automation of Pressure Control Improves Whole Porcine Heart Decellularization.

  title={Automation of Pressure Control Improves Whole Porcine Heart Decellularization.},
  author={Nima Momtahan and Nafiseh Poornejad and Jeremy A Struk and Arthur A Castleton and Brenden J Herrod and Brady R Vance and Jordan P Eatough and Beverly L. Roeder and Paul R Reynolds and Alonzo David Cook},
  journal={Tissue engineering. Part C, Methods},
  volume={21 11},
Whole heart decellularization combined with patient-specific cells may prove to be an extremely valuable approach to engineer new hearts. Mild detergents are commonly used in the decellularization process, but are known to denature and solubilize key proteins and growth factors and can therefore be destructive to the extracellular matrix (ECM) during the decellularization process. In this study, the decellularization of porcine hearts was accomplished in 24 h with only 6 h of sodium dodecyl… CONTINUE READING
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