Automation of [11C]acyl chloride syntheses using commercially available 11C-modules.

@article{Matarrese2002AutomationO,
  title={Automation of [11C]acyl chloride syntheses using commercially available 11C-modules.},
  author={Mario Matarrese and Francesco Sudati and Dmitri Soloviev and Sergio Todde and Elia Anna Turolla and Marzia Galli Kienle and Ferruccio Fazio},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={2002},
  volume={57 5},
  pages={
          675-9
        }
}
In implementing published procedures for the incorporation of [11C]carbon dioxide on the immobilized Grignard reagents for the radiosynthesis of [11C]acyl chlorides, several modifications on a commercial PET tracer synthesizer module for 11C-methylations were made to obtain reliable and reproducible production processes for routine clinical applications. High yields of [carbonyl-11C]WAY-100635 and [11C]zofenoprilat were obtained via 11C-carboxylation using [carbonyl-11C]cyclohexanecarbonyl… CONTINUE READING

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Simple and fully automated preparation of [carbonyl-11C]WAY-100635

Wolfgang Wadsak, Leonhard-Key Mien, +5 authors Markus Mitterhauser
  • 2007
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A fully automated one-pot synthesis of [carbonyl-11C]WAY-100635 for clinical PET applications.

  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2009
VIEW 1 EXCERPT
CITES BACKGROUND
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